Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 272)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1479932	0.1424611	0.3106967
Weighted median	23	-0.0445513	0.0650386	0.4933456
Inverse variance weighted	23	0.0099169	0.0562493	0.8600563
Simple mode	23	0.0267545	0.1103296	0.8106420
Weighted mode	23	-0.0793313	0.0986891	0.4300842

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.77594	21	0.0033570
Inverse variance weighted	45.72991	22	0.0021419

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096973	0.0080526	0.2418944

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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