Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 271)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0805818	0.1078960	0.4634367
Weighted median	23	0.0599290	0.0598597	0.3167504
Inverse variance weighted	23	-0.0116243	0.0420395	0.7821567
Simple mode	23	-0.1339486	0.1150886	0.2569426
Weighted mode	23	0.0766542	0.0581231	0.2007919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.53555	21	0.2678396
Inverse variance weighted	25.54267	22	0.2718342

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056624	0.0060988	0.3637295

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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