Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 270)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0088011	0.1307416	0.9469663
Weighted median	23	0.1462950	0.0605201	0.0156363
Inverse variance weighted	23	0.0544276	0.0500972	0.2772847
Simple mode	23	0.2086938	0.1195798	0.0948997
Weighted mode	23	0.1469831	0.0762948	0.0670563

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.02702	21	0.0217129
Inverse variance weighted	36.27363	22	0.0283773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028019	0.0073902	0.7083886

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011581	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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