Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 27)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0182568	0.0998201	0.8566333
Weighted median	23	-0.0782206	0.0572400	0.1717708
Inverse variance weighted	23	0.0065829	0.0390155	0.8660128
Simple mode	23	-0.1105702	0.0964881	0.2641295
Weighted mode	23	-0.0763932	0.0639202	0.2447595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.97946	21	0.5864577
Inverse variance weighted	19.05255	22	0.6420812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015254	0.0056423	0.7895298

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005782	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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