Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 269)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1206326	0.0998203	0.2402887
Weighted median	23	-0.0745632	0.0551458	0.1763401
Inverse variance weighted	23	-0.0143410	0.0390155	0.7131927
Simple mode	23	0.0693847	0.1084758	0.5290162
Weighted mode	23	-0.0857887	0.0641320	0.1946631

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.70440	21	0.6040958
Inverse variance weighted	20.04272	22	0.5803675

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065274	0.0056423	0.260322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006114	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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