Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 268)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0888120	0.1066766	0.4144753
Weighted median	23	-0.0598325	0.0558617	0.2841321
Inverse variance weighted	23	-0.0504844	0.0408846	0.2169039
Simple mode	23	-0.0428765	0.1030309	0.6813309
Weighted mode	23	-0.0732342	0.0655148	0.2756996

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.98453	21	0.2938088
Inverse variance weighted	24.15855	22	0.3389738

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023537	0.0060299	0.7002167

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007828	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8