Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 267)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0550980 0.1096105 0.6204267
Weighted median 23 0.0461972 0.0627177 0.4613720
Inverse variance weighted 23 0.0385815 0.0418837 0.3569685
Simple mode 23 0.0005740 0.1103903 0.9958984
Weighted mode 23 0.0222073 0.0807329 0.7858285

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 25.32162 21 0.2335032
Inverse variance weighted 25.35394 22 0.2804503

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0010143 0.0061957 0.8715275

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007979 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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