Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 266)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2001801	0.1302019	0.1391126
Weighted median	23	-0.0654193	0.0637327	0.3046733
Inverse variance weighted	23	-0.0589590	0.0549775	0.2835313
Simple mode	23	-0.2942104	0.1337595	0.0386430
Weighted mode	23	-0.0929135	0.0806673	0.2617620

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.72988	21	0.0234423
Inverse variance weighted	43.68493	22	0.0038824

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0159138	0.0073597	0.0422858

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013929	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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