Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 265)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0042941	0.1097876	0.9691700
Weighted median	23	0.0148136	0.0560419	0.7915253
Inverse variance weighted	23	-0.0229364	0.0419973	0.5849709
Simple mode	23	0.0597332	0.0827947	0.4782235
Weighted mode	23	0.0180390	0.0592164	0.7635119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.40340	21	0.2301157
Inverse variance weighted	25.49123	22	0.2741652

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016722	0.0062057	0.7902026

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007829	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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