Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 264)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0306496	0.1278330	0.8128387
Weighted median	23	0.0245488	0.0660523	0.7101485
Inverse variance weighted	23	-0.0620138	0.0488980	0.2047169
Simple mode	23	0.0744973	0.1123315	0.5140976
Weighted mode	23	0.0673239	0.0776083	0.3950410

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.44044	21	0.0324918
Inverse variance weighted	34.55697	22	0.0430754

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019261	0.0072258	0.7924105

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011236	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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