Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 262)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0175575	0.1095373	0.8741863
Weighted median	23	-0.0440675	0.0577836	0.4456834
Inverse variance weighted	23	-0.0244755	0.0420020	0.5600804
Simple mode	23	-0.0435541	0.0924335	0.6421416
Weighted mode	23	-0.0435541	0.0722810	0.5529586

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.28789	21	0.2349108
Inverse variance weighted	25.49718	22	0.2738951

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025812	0.0061916	0.6809853

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007846	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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