Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 261)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0552318	0.0998207	0.5858942
Weighted median	23	-0.0300626	0.0543385	0.5800948
Inverse variance weighted	23	-0.0109828	0.0390156	0.7783291
Simple mode	23	-0.0002273	0.0854927	0.9979026
Weighted mode	23	-0.0210635	0.0599264	0.7285649

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.51640	21	0.9517635
Inverse variance weighted	12.03576	22	0.9566362

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040662	0.0056423	0.479063

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003671	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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