Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 260)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0130099	0.0998213	0.8975441
Weighted median	23	-0.0446039	0.0534319	0.4038413
Inverse variance weighted	23	-0.0148512	0.0390158	0.7034667
Simple mode	23	-0.0209448	0.0842635	0.8060041
Weighted mode	23	-0.0365137	0.0654268	0.5824220

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.22975	21	0.9003636
Inverse variance weighted	13.23015	22	0.9265431

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001131	0.0056424	0.984201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004053	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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