Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 26)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1770537	0.1066342	0.1116968
Weighted median	23	0.0390287	0.0559709	0.4856127
Inverse variance weighted	23	0.0266898	0.0429354	0.5341875
Simple mode	23	-0.0328517	0.1005591	0.7469894
Weighted mode	23	0.0309919	0.0851638	0.7193991

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.96492	21	0.2947613
Inverse variance weighted	26.64316	22	0.2250941

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092339	0.0060275	0.1404607

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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