Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 259)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1865935	0.1079048	0.0984401
Weighted median	23	0.0587533	0.0581132	0.3120088
Inverse variance weighted	23	0.0106223	0.0441789	0.8099910
Simple mode	23	-0.0920852	0.0930285	0.3330052
Weighted mode	23	0.0665905	0.0666667	0.3287242

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.54025	21	0.2676244
Inverse variance weighted	28.20853	22	0.1688727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108064	0.0060993	0.0909484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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