Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 258)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1450813	0.0998209	0.1608898
Weighted median	23	0.0049506	0.0547934	0.9280086
Inverse variance weighted	23	0.0251050	0.0390156	0.5199262
Simple mode	23	0.0019449	0.0883468	0.9826349
Weighted mode	23	0.0297047	0.0626472	0.6400598

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.86848	21	0.8294926
Inverse variance weighted	16.57357	22	0.7864369

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073677	0.0056424	0.2057484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8