Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 257)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1316764	0.1128395	0.2563171
Weighted median	23	0.0169485	0.0564915	0.7641631
Inverse variance weighted	23	-0.0168456	0.0451391	0.7090048
Simple mode	23	-0.0390986	0.1112875	0.7286837
Weighted mode	23	0.0392096	0.0620739	0.5341179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.83491	21	0.1763848
Inverse variance weighted	29.44790	22	0.1325120

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0091207	0.0063782	0.1674345

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000898	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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