Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 256)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0149863	0.1084342	0.8913937
Weighted median	23	0.0251103	0.0625825	0.6882467
Inverse variance weighted	23	0.0471570	0.0417882	0.2591180
Simple mode	23	0.0291264	0.1160498	0.8041576
Weighted mode	23	0.0121389	0.0730029	0.8694558

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.78054	21	0.2567941
Inverse variance weighted	25.23799	22	0.2858295

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038162	0.0061292	0.5402332

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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