Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 255)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1991202	0.1198639	0.1115273
Weighted median	23	0.0413443	0.0587585	0.4816628
Inverse variance weighted	23	-0.0119586	0.0496014	0.8094826
Simple mode	23	0.0740432	0.0852288	0.3943588
Weighted mode	23	0.0568068	0.0608612	0.3607543

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.27993	21	0.0865055
Inverse variance weighted	35.55765	22	0.0338481

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0129622	0.0067752	0.0694577

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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