Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 254)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1166093 0.1238608 0.3571768
Weighted median 23 0.1479357 0.0598321 0.0134166
Inverse variance weighted 23 0.0644934 0.0475336 0.1748460
Simple mode 23 0.0696833 0.1137130 0.5462920
Weighted mode 23 0.0960195 0.0742401 0.2093015

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 32.33385 21 0.0541458
Inverse variance weighted 32.65559 22 0.0668857

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0032004 0.0070012 0.6522742

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0010724 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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