Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 253)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0010099	0.0998213	0.9920237
Weighted median	23	-0.0380130	0.0549201	0.4888422
Inverse variance weighted	23	-0.0012542	0.0390158	0.9743558
Simple mode	23	-0.0249683	0.0884908	0.7804604
Weighted mode	23	-0.0440592	0.0635184	0.4951648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.73674	21	0.8359262
Inverse variance weighted	14.73674	22	0.8732858

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-1.5e-05	0.0056424	0.9979033

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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