Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 252)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1093620	0.0998203	0.2856653
Weighted median	23	0.0371294	0.0543846	0.4947843
Inverse variance weighted	23	0.0190652	0.0390154	0.6250841
Simple mode	23	0.0351200	0.0915409	0.7049177
Weighted mode	23	0.0687172	0.0693705	0.3326600

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.31279	21	0.8557921
Inverse variance weighted	15.27863	22	0.8500054

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055451	0.0056423	0.3369081

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004702	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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