Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 251)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1675580	0.0998204	0.1080515
Weighted median	23	0.0512257	0.0531161	0.3348406
Inverse variance weighted	23	0.0552629	0.0390157	0.1566503
Simple mode	23	0.0374479	0.0918808	0.6875277
Weighted mode	23	0.0572837	0.0686125	0.4127568

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.70559	21	0.9472269
Inverse variance weighted	13.19935	22	0.9274519

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068961	0.0056424	0.2351753

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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