Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 250)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2409315	0.0998192	0.0250088
Weighted median	23	-0.0332095	0.0597377	0.5782648
Inverse variance weighted	23	0.0047974	0.0391308	0.9024248
Simple mode	23	-0.1008623	0.1222806	0.4183148
Weighted mode	23	0.0164622	0.0824645	0.8436052

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.52537	21	0.7956982
Inverse variance weighted	22.13060	22	0.4521169

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0145011	0.0056423	0.0178463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006711	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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