Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 25)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0177440	0.1065150	0.8692884
Weighted median	23	-0.0191550	0.0584297	0.7430402
Inverse variance weighted	23	-0.0156249	0.0406756	0.7008794
Simple mode	23	0.0757419	0.0953963	0.4356934
Weighted mode	23	-0.0162700	0.0664438	0.8088278

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.91130	21	0.2973764
Inverse variance weighted	23.91183	22	0.3518682

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001301	0.0060207	0.982959

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007294	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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