Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 249)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1477844	0.0998199	0.1535852
Weighted median	23	0.0215676	0.0559622	0.6999438
Inverse variance weighted	23	0.0213008	0.0390158	0.5850976
Simple mode	23	0.0137615	0.0785780	0.8625782
Weighted mode	23	0.0169004	0.0630860	0.7912764

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.67926	21	0.8829782
Inverse variance weighted	15.57436	22	0.8364340

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0077673	0.0056423	0.1831282

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000481	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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