Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 248)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0368232	0.1003608	0.7173585
Weighted median	23	0.0262119	0.0529061	0.6202877
Inverse variance weighted	23	0.0682366	0.0394877	0.0839797
Simple mode	23	0.0722636	0.0965368	0.4620509
Weighted mode	23	0.0357121	0.0566838	0.5351691

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.22820	21	0.4450858
Inverse variance weighted	22.53569	22	0.4283308

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064517	0.0056729	0.2682268

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007756	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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