Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 247)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1085996	0.1095760	0.3329250
Weighted median	23	-0.0124831	0.0580546	0.8297490
Inverse variance weighted	23	0.0076026	0.0431459	0.8601313
Simple mode	23	0.0386775	0.0981022	0.6971866
Weighted mode	23	0.0014452	0.0637837	0.9821280

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.30541	21	0.2341791
Inverse variance weighted	26.90493	22	0.2148597

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007136	0.0061938	0.2622192

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008164	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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