Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 246)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1250468 0.1121506 0.2774525
Weighted median 23 -0.0390635 0.0578899 0.4998102
Inverse variance weighted 23 -0.0488870 0.0456311 0.2840113
Simple mode 23 -0.0144433 0.1092890 0.8960612
Weighted mode 23 -0.0144433 0.0759181 0.8508586

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 26.50967 21 0.1876783
Inverse variance weighted 30.09353 22 0.1162088

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0106812 0.0063392 0.1068059

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0009593 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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