Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 245)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0937531	0.0998212	0.3583006
Weighted median	23	-0.0456284	0.0556543	0.4122999
Inverse variance weighted	23	0.0144272	0.0390157	0.7115462
Simple mode	23	-0.0270844	0.0847428	0.7522812
Weighted mode	23	-0.0410430	0.0616458	0.5124680

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.15957	21	0.9352095
Inverse variance weighted	13.54585	22	0.9168117

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066433	0.0056424	0.2522072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004146	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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