Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 244)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0691487	0.0998201	0.4960673
Weighted median	23	0.0229193	0.0583246	0.6943479
Inverse variance weighted	23	-0.0024276	0.0390157	0.9503861
Simple mode	23	-0.0522718	0.1012391	0.6107821
Weighted mode	23	0.0281835	0.0663551	0.6751526

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.34339	21	0.5631219
Inverse variance weighted	19.95027	22	0.5861504

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043955	0.0056423	0.4446562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006047	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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