Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 243)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0002223	0.0998203	0.9982444
Weighted median	23	0.0187792	0.0564339	0.7393118
Inverse variance weighted	23	-0.0510206	0.0390157	0.1909763
Simple mode	23	-0.1848005	0.1118201	0.1126019
Weighted mode	23	-0.0043528	0.0658482	0.9478923

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.39302	21	0.6240155
Inverse variance weighted	18.69869	22	0.6638532

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031195	0.0056423	0.586184

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006185	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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