Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 242)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1736554	0.1073579	0.1206857
Weighted median	23	0.0290312	0.0571293	0.6113366
Inverse variance weighted	23	-0.0317335	0.0450169	0.4808585
Simple mode	23	-0.0730724	0.1014076	0.4787544
Weighted mode	23	0.0148870	0.0707357	0.8352465

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.29174	21	0.2791388
Inverse variance weighted	29.28891	22	0.1367957

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0126129	0.0060684	0.0501157

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009075	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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