Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 241)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0840316	0.1240624	0.5055888
Weighted median	23	-0.0169048	0.0571822	0.7675127
Inverse variance weighted	23	-0.0260136	0.0476664	0.5852430
Simple mode	23	-0.2557518	0.0974934	0.0155230
Weighted mode	23	-0.0122607	0.0562481	0.8294572

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.43898	21	0.0528201
Inverse variance weighted	32.83772	22	0.0641933

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035629	0.0070126	0.6167009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010085	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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