Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 240)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1171527	0.0998209	0.2536832
Weighted median	23	0.0475739	0.0537396	0.3760124
Inverse variance weighted	23	0.0315804	0.0390157	0.4182689
Simple mode	23	-0.0163053	0.0807739	0.8418782
Weighted mode	23	0.0525249	0.0580801	0.3756061

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.33659	21	0.9558245
Inverse variance weighted	12.20399	22	0.9530219

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005255	0.0056424	0.3622591

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003897	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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