Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 24)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1350350	0.0998200	0.1905110
Weighted median	23	0.0205575	0.0577352	0.7217910
Inverse variance weighted	23	-0.0291684	0.0390156	0.4546967
Simple mode	23	-0.2017800	0.1060709	0.0703022
Weighted mode	23	0.0374581	0.0774187	0.6332819

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.38550	21	0.7476152
Inverse variance weighted	19.57945	22	0.6093274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0100837	0.0056423	0.0883549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006103	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8