Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 239)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0006660	0.0998206	0.9947399
Weighted median	23	-0.0096299	0.0564615	0.8645725
Inverse variance weighted	23	0.0221613	0.0390158	0.5700286
Simple mode	23	-0.0326428	0.0893107	0.7182307
Weighted mode	23	0.0006237	0.0652596	0.9924605

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.62449	21	0.7903643
Inverse variance weighted	15.68622	22	0.8311477

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014018	0.0056423	0.806202

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004851	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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