Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 238)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0665303	0.0998192	0.5123433
Weighted median	23	0.0077430	0.0568353	0.8916349
Inverse variance weighted	23	0.0065630	0.0390153	0.8664131
Simple mode	23	0.0430650	0.1040234	0.6828872
Weighted mode	23	0.0328433	0.0735754	0.6596783

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.62621	21	0.5450355
Inverse variance weighted	20.05220	22	0.5797746

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036826	0.0056423	0.5210447

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006085	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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