Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 237)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0751343	0.1108001	0.5051080
Weighted median	23	0.0811395	0.0558180	0.1460455
Inverse variance weighted	23	0.0877461	0.0448077	0.0501967
Simple mode	23	0.1010078	0.0918681	0.2834420
Weighted mode	23	0.0625704	0.0640880	0.3395204

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.87425	21	0.2112844
Inverse variance weighted	29.01697	22	0.1443769

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100024	0.0062629	0.1251856

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010325	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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