Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 236)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0310044 0.1048614 0.7703859
Weighted median 23 -0.0091983 0.0557057 0.8688476
Inverse variance weighted 23 0.0279940 0.0400443 0.4845044
Simple mode 23 -0.1025739 0.0891226 0.2621173
Weighted mode 23 -0.0420356 0.0672370 0.5382804

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.17431 21 0.3347553
Inverse variance weighted 23.17539 22 0.3918834

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0001849 0.0059273 0.9754133

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007178 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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