Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 235)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0392158	0.0998207	0.6983802
Weighted median	23	-0.0054327	0.0554498	0.9219522
Inverse variance weighted	23	-0.0020889	0.0390155	0.9573004
Simple mode	23	-0.0154324	0.0901338	0.8656186
Weighted mode	23	0.0069799	0.0657177	0.9163781

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.88432	21	0.4660278
Inverse variance weighted	21.08642	22	0.5154027

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025365	0.0056423	0.65764

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006391	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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