Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 234)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0021489	0.1000521	0.9830673
Weighted median	23	0.0552387	0.0569188	0.3318055
Inverse variance weighted	23	0.0613097	0.0390155	0.1160851
Simple mode	23	-0.0053571	0.0936368	0.9548928
Weighted mode	23	0.0386070	0.0638234	0.5514320

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.09774	21	0.4529890
Inverse variance weighted	21.51235	22	0.4892969

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036331	0.0056554	0.5275632

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007267	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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