Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 233)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0653006	0.0998201	0.5200946
Weighted median	23	0.0935252	0.0572927	0.1025929
Inverse variance weighted	23	0.0393042	0.0390154	0.3137415
Simple mode	23	0.1407391	0.1004725	0.1752301
Weighted mode	23	0.1054281	0.0691434	0.1415630

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.75574	21	0.4739456
Inverse variance weighted	20.83579	22	0.5309054

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015964	0.0056423	0.7799931

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006621	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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