Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 232)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0752485	0.1049430	0.4812483
Weighted median	23	-0.0154150	0.0579440	0.7902144
Inverse variance weighted	23	-0.0144902	0.0408898	0.7230595
Simple mode	23	-0.1335767	0.1125777	0.2480694
Weighted mode	23	-0.1038001	0.0810813	0.2138100

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.21078	21	0.3328440
Inverse variance weighted	24.16472	22	0.3386548

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055109	0.0059319	0.3634347

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007365	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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