Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 230)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0813600	0.0998194	0.4241792
Weighted median	23	0.0213099	0.0553561	0.7002671
Inverse variance weighted	23	0.0185894	0.0390156	0.6337454
Simple mode	23	-0.0027901	0.0924968	0.9762084
Weighted mode	23	0.0629207	0.0724965	0.3948106

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.15728	21	0.5750515
Inverse variance weighted	20.34068	22	0.5617390

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061379	0.0056423	0.2889936

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006232	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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