Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 227)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1225535	0.0998209	0.2331312
Weighted median	23	0.0931152	0.0548541	0.0896009
Inverse variance weighted	23	0.0768963	0.0390159	0.0487358
Simple mode	23	0.0412255	0.0895010	0.6495956
Weighted mode	23	0.0829491	0.0634599	0.2046733

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.10807	21	0.9774744
Inverse variance weighted	10.35500	22	0.9827904

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028038	0.0056424	0.6244067

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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