Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 226)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1911859	0.0998198	0.0691711
Weighted median	23	0.0903747	0.0537950	0.0929606
Inverse variance weighted	23	0.0625635	0.0390154	0.1088114
Simple mode	23	0.1399388	0.0925025	0.1445617
Weighted mode	23	0.1166044	0.0684595	0.1026068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.80814	21	0.9151954
Inverse variance weighted	14.76788	22	0.8720055

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078987	0.0056423	0.1761416

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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