Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 225)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0105490	0.1087175	0.9236220
Weighted median	23	-0.0228541	0.0581266	0.6941881
Inverse variance weighted	23	0.0068347	0.0415459	0.8693300
Simple mode	23	0.1396572	0.0965848	0.1622869
Weighted mode	23	-0.0492653	0.0770948	0.5294064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.91051	21	0.2510607
Inverse variance weighted	24.94631	22	0.2996493

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010675	0.0061453	0.8637521

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007568	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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