Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 224)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1448686	0.0998208	0.1614757
Weighted median	23	0.0344058	0.0540951	0.5247605
Inverse variance weighted	23	-0.0163831	0.0390158	0.6745519
Simple mode	23	0.0370806	0.0914053	0.6889019
Weighted mode	23	0.0469119	0.0627376	0.4625313

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.83348	21	0.9440046
Inverse variance weighted	14.91358	22	0.8659200

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0099024	0.0056423	0.0938354

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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