Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 223)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3205481	0.1007370	0.0044866
Weighted median	23	0.0095494	0.0587047	0.8707799
Inverse variance weighted	23	0.0000237	0.0481866	0.9996084
Simple mode	23	0.0113718	0.1020640	0.9122952
Weighted mode	23	0.0018005	0.0811908	0.9825073

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.38849	21	0.4354493
Inverse variance weighted	33.55893	22	0.0544324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0196835	0.0056942	0.0023609

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010169	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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